Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
agtr1_human 56 1.60x60 TM1 Y => IlefsTer2 frameshift 1.649e-05 2 121322 0 None None
agtr1_human 100 3.24x24 TM3 L => TyrfsTer35 frameshift 2.487e-05 3 120622 0 None None
agtr1_human 113 3.37x37 TM3 Y => LeufsTer3 frameshift 1.663e-05 2 120248 0 None None LB (hydrophobic, Van der Waals)
agtr1_human 114 3.38x38 TM3 A => LeufsTer21 frameshift 8.319e-06 1 120212 0 None None
agtr1_human 126 3.50x50 TM3 R => Ter stop gained 1.667e-05 2 119974 0 None None SodiumPocket MicroSwitch GP (contact)
agtr1_human 167 4.64x65 TM4 R => Ter stop gained 8.25e-06 1 121210 0 None None LB (polar (charge-assisted hydrogen bond))
agtr1_human 171 ECL2 F => HisfsTer2 frameshift 8.249e-06 1 121224 0 None None
agtr1_human 248 6.43x43 TM6 F => LeufsTer25 frameshift 2.492e-05 3 120376 0 None None
agtr1_human 257 6.52x52 TM6 Q => Ter stop gained 8.287e-06 1 120676 0 None None
agtr1_human 347 C-term S => Ter stop gained 8.287e-06 1 120666 0 None None
agtr1_human 2 N-term I => V missense 4.972e-05 6 120664 0 nan 0.0
agtr1_human 2 N-term I => F missense 1.657e-05 2 120664 0 nan 0.024
agtr1_human 2 N-term I => S missense 8.287e-06 1 120666 0 nan 0.0
agtr1_human 4 N-term N => H missense 8.282e-06 1 120750 0 0.02 0.825
agtr1_human 10 N-term G => V missense 4.96e-05 6 120974 0 0.26 0.034
agtr1_human 11 N-term I => V missense 8.265e-06 1 120986 0 0.48 0.001
agtr1_human 27 1.31x31 TM1 I => V missense 1.649e-05 2 121280 0 0.63 0.16
agtr1_human 28 1.32x32 TM1 F => L missense 8.245e-06 1 121288 0 0.07 0.038
agtr1_human 36 1.40x40 TM1 S => C missense 1.648e-05 2 121344 0 0.09 0.847
agtr1_human 36 1.40x40 TM1 S => N missense 1.648e-05 2 121346 0 0.03 0.372
agtr1_human 38 1.42x42 TM1 I => T missense 8.24e-06 1 121352 0 0.1 0.948
agtr1_human 49 1.53x53 TM1 V => L missense 8.241e-06 1 121350 0 0.0 0.974
agtr1_human 49 1.53x53 TM1 V => A missense 8.241e-06 1 121350 0 0.0 0.993
agtr1_human 52 1.56x56 TM1 V => G missense 7.417e-05 9 121338 0 0.0 0.824
agtr1_human 57 12.48x48 ICL1 M => T missense 2.473e-05 3 121322 0 0.26 0.886
agtr1_human 58 12.49x49 ICL1 K => T missense 8.243e-06 1 121320 0 0.07 0.998
agtr1_human 59 12.50x50 ICL1 L => P missense 1.649e-05 2 121302 0 0.14 0.904
agtr1_human 65 2.41x41 TM2 V => I missense 0.000363 44 121220 0 1.0 0.003
agtr1_human 77 2.53x53 TM2 F => C missense 8.262e-06 1 121030 0 0.23 1.0 LB (hydrophobic, Van der Waals)
agtr1_human 85 2.61x61 TM2 A => T missense 8.266e-06 1 120982 0 0.0 1.0
agtr1_human 85 2.61x61 TM2 A => D missense 8.266e-06 1 120980 0 0.0 1.0
agtr1_human 86 2.62x62 TM2 V => L missense 8.266e-06 1 120984 0 0.07 0.174
agtr1_human 87 2.63x63 TM2 Y => C missense 8.266e-06 1 120984 0 0.01 0.956 LB (Van der Waals, polar (hydrogen bond))
agtr1_human 90 2.66x66 TM2 M => V missense 8.271e-06 1 120908 0 0.21 0.703
agtr1_human 93 23.49x49 ECL1 R => H missense 1.656e-05 2 120790 0 1.0 0.001
agtr1_human 101 3.25x25 TM3 C => R missense 8.292e-06 1 120604 0 0.0 1.0
agtr1_human 103 3.27x27 TM3 I => F missense 6.636e-05 8 120556 0 0.03 0.076
agtr1_human 103 3.27x27 TM3 I => T missense 0.0007549 91 120540 0 0.25 0.046
agtr1_human 108 3.32x32 TM3 V => I missense 2.492e-05 3 120380 0 0.59 0.005 LB (hydrophobic, Van der Waals)
agtr1_human 109 3.33x33 TM3 S => R missense 8.307e-06 1 120384 0 0.06 0.894 LB (Van der Waals, polar (hydrogen bond))
agtr1_human 112 3.36x36 TM3 L => R missense 8.316e-06 1 120248 0 0.0 0.996 LB (Van der Waals, hydrophobic)
agtr1_human 114 3.38x38 TM3 A => T missense 4.159e-05 5 120208 0 0.6 0.065
agtr1_human 115 3.39x39 TM3 S => T missense 0.0002828 34 120210 0 0.11 0.507
agtr1_human 120 3.44x44 TM3 T => M missense 1.666e-05 2 120070 0 0.02 0.903
agtr1_human 120 3.44x44 TM3 T => R missense 8.328e-06 1 120070 0 0.0 0.991
agtr1_human 126 3.50x50 TM3 R => Q missense 0.0001 12 119996 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
agtr1_human 132 3.56x56 TM3 H => N missense 8.332e-06 1 120016 0 0.0 0.911 GP (contact)
agtr1_human 134 34.51x51 ICL2 M => V missense 6.662e-05 8 120086 0 0.89 0.015 GP (contact)
agtr1_human 136 34.53x53 ICL2 S => Y missense 8.324e-06 1 120128 0 0.0 0.954 GP (contact)
agtr1_human 137 34.54x54 ICL2 R => H missense 1.665e-05 2 120152 0 0.03 0.999 GP (contact)
agtr1_human 139 34.56x56 ICL2 R => Q missense 8.319e-06 1 120210 0 0.29 0.256 GP (contact)
agtr1_human 140 34.57x57 ICL2 R => C missense 5.821e-05 7 120248 0 0.0 1.0 GP (contact)
agtr1_human 140 34.57x57 ICL2 R => H missense 4.157e-05 5 120268 0 0.0 1.0 GP (contact)
agtr1_human 143 4.40x40 TM4 L => I missense 3.321e-05 4 120440 0 0.52 0.026
agtr1_human 156 4.53x53 TM4 A => T missense 8.273e-06 1 120872 0 0.0 0.989
agtr1_human 163 4.60x61 TM4 A => T missense 0.0006688 81 121118 1 1.0 0.001 LB (Van der Waals)
agtr1_human 167 4.64x65 TM4 R => Q missense 3.3e-05 4 121214 0 0.0 0.995 LB (polar (charge-assisted hydrogen bond))
agtr1_human 172 ECL2 I => T missense 1.65e-05 2 121216 0 0.02 0.345
agtr1_human 176 ECL2 N => S missense 8.252e-06 1 121190 0 0.06 0.965
agtr1_human 179 ECL2 V => L missense 1.651e-05 2 121166 0 0.13 0.153
agtr1_human 184 ECL2 Y => H missense 1.652e-05 2 121090 0 0.47 0.465
agtr1_human 185 ECL2 E => K missense 8.26e-06 1 121064 0 0.75 0.002
agtr1_human 186 ECL2 S => P missense 8.261e-06 1 121048 0 0.15 0.15
agtr1_human 188 ECL2 N => Y missense 5.786e-05 7 120992 0 0.34 0.074
agtr1_human 189 ECL2 S => L missense 8.273e-06 1 120870 0 0.32 0.049
agtr1_human 191 5.34x35 TM5 L => F missense 8.275e-06 1 120844 0 0.2 0.009
agtr1_human 192 5.35x36 TM5 P => L missense 4.972e-05 6 120672 0 0.75 0.0 LB (hydrophobic, Van der Waals)
agtr1_human 197 5.40x41 TM5 L => Q missense 8.294e-06 1 120570 0 0.0 0.994
agtr1_human 208 5.51x51 TM5 F => L missense 3.322e-05 4 120426 0 0.74 0.204
agtr1_human 218 5.61x61 TM5 I => S missense 8.306e-06 1 120398 0 0.0 1.0 GP (contact)
agtr1_human 221 5.64x64 TM5 A => D missense 8.306e-06 1 120400 0 0.15 0.292 GP (contact)
agtr1_human 231 ICL3 N => T missense 8.308e-06 1 120370 0 0.13 0.046
agtr1_human 233 6.28x28 TM6 P => T missense 5.816e-05 7 120348 0 0.58 0.001 GP (contact)
agtr1_human 236 6.31x31 TM6 D => H missense 2.494e-05 3 120296 0 0.0 0.998
agtr1_human 236 6.31x31 TM6 D => A missense 8.311e-06 1 120320 0 0.0 0.996
agtr1_human 237 6.32x32 TM6 D => E missense 8.311e-06 1 120316 0 1.0 0.014 GP (contact)
agtr1_human 240 6.35x35 TM6 K => N missense 8.31e-06 1 120330 0 0.04 0.075
agtr1_human 242 6.37x37 TM6 I => T missense 8.309e-06 1 120356 0 0.01 0.984 GP (contact)
agtr1_human 243 6.38x38 TM6 M => I missense 8.308e-06 1 120366 0 0.74 0.001
agtr1_human 244 6.39x39 TM6 A => S missense 0.004055 488 120352 6 0.03 0.492
agtr1_human 245 6.40x40 TM6 I => V missense 7.476e-05 9 120392 0 1.0 0.03 GP (contact)
agtr1_human 245 6.40x40 TM6 I => T missense 8.307e-06 1 120386 0 0.08 0.114 GP (contact)
agtr1_human 246 6.41x41 TM6 V => L missense 8.308e-06 1 120372 0 0.0 0.987
agtr1_human 248 6.43x43 TM6 F => L missense 4.983e-05 6 120404 1 1.0 0.002
agtr1_human 248 6.43x43 TM6 F => C missense 8.305e-06 1 120408 0 0.07 0.421
agtr1_human 256 6.51x51 TM6 H => N missense 8.29e-06 1 120630 0 0.11 0.98 LB (Van der Waals)
agtr1_human 258 6.53x53 TM6 I => T missense 8.28e-06 1 120778 0 0.01 0.608
agtr1_human 260 6.55x55 TM6 T => I missense 8.272e-06 1 120888 0 0.04 0.565
agtr1_human 263 6.58x58 TM6 D => G missense 8.264e-06 1 121012 0 0.01 0.915 LB (polar (charge-assisted hydrogen bond))
agtr1_human 269 6.64x64 TM6 G => S missense 1.651e-05 2 121146 0 0.66 0.033
agtr1_human 270 ECL3 I => V missense 8.253e-06 1 121166 0 1.0 0.001
agtr1_human 272 ECL3 R => C missense 2.475e-05 3 121192 0 0.05 0.443
agtr1_human 278 7.29x28 TM7 D => G missense 8.25e-06 1 121216 0 0.4 0.953
agtr1_human 283 7.34x33 TM7 A => T missense 8.25e-06 1 121218 0 0.06 0.926
agtr1_human 287 7.38x37 TM7 T => I missense 8.25e-06 1 121210 0 0.03 1.0
agtr1_human 288 7.39x38 TM7 I => V missense 8.25e-06 1 121210 0 0.0 0.779 LB (hydrophobic, Van der Waals)
agtr1_human 288 7.39x38 TM7 I => M missense 8.25e-06 1 121208 0 0.0 0.998 LB (hydrophobic, Van der Waals)
agtr1_human 289 7.40x39 TM7 C => Y missense 8.25e-06 1 121210 0 0.0 1.0 PTM (S-nitrosylation)
agtr1_human 290 7.41x40 TM7 I => V missense 1.65e-05 2 121212 0 0.16 0.058
agtr1_human 292 7.43x42 TM7 Y => C missense 1.65e-05 2 121186 0 0.0 0.998 LB (hydrophobic, Van der Waals)
agtr1_human 293 7.44x43 TM7 F => C missense 8.252e-06 1 121186 0 0.05 0.995 SodiumPocket MicroSwitch
agtr1_human 298 7.49x49 TM7 N => S missense 4.953e-05 6 121138 0 0.0 0.999 SodiumPocket MicroSwitch
agtr1_human 302 7.53x53 TM7 Y => C missense 8.262e-06 1 121040 0 0.0 1.0 SodiumPocket MicroSwitch PTM (Phosphorylation)
agtr1_human 309 8.50x50 H8 F => I missense 8.286e-06 1 120688 0 0.0 0.548
agtr1_human 314 8.55x55 H8 L => R missense 7.477e-05 9 120376 0 0.34 0.962
agtr1_human 315 8.56x56 H8 Q => P missense 8.306e-06 1 120402 0 0.04 0.795
agtr1_human 318 8.59x59 H8 K => T missense 8.306e-06 1 120392 0 0.02 0.328
agtr1_human 318 8.59x59 H8 K => N missense 1.661e-05 2 120380 0 0.02 0.4
agtr1_human 325 C-term K => R missense 0.0001494 18 120506 0 1.0 0.0
agtr1_human 327 C-term H => P missense 8.295e-06 1 120554 0 0.01 0.261
agtr1_human 334 C-term M => I missense 5.804e-05 7 120604 0 0.17 0.002
agtr1_human 336 C-term T => M missense 5.804e-05 7 120598 0 0.06 0.005 PTM (Phosphorylation)
agtr1_human 339 C-term Y => C missense 1.658e-05 2 120628 0 0.04 0.944
agtr1_human 340 C-term R => C missense 8.29e-06 1 120626 0 0.04 0.013
agtr1_human 340 C-term R => H missense 1.658e-05 2 120620 0 0.05 0.008
agtr1_human 344 C-term N => Y missense 8.288e-06 1 120652 0 0.07 0.068
agtr1_human 349 C-term T => I missense 9.944e-05 12 120678 0 0.13 0.0
agtr1_human 350 C-term K => R missense 8.286e-06 1 120688 0 0.34 0.009
agtr1_human 351 C-term K => M missense 8.285e-06 1 120694 0 0.06 0.868
agtr1_human 352 C-term P => S missense 8.285e-06 1 120706 0 0.78 0.0
agtr1_human 354 C-term P => L missense 8.284e-06 1 120718 0 0.79 0.0
agtr1_human 356 C-term F => V missense 3.314e-05 4 120714 0 nan 0.0


Residue

Diagrams

ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
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